There are two types of premature ejaculation pills, also called stamina pills - herbal and pharmaceutical. None of the herbal pills have been scientifically proven to help PE. Pharmaceuticals, antidepressants in the form of SSRIs have been shown to be effective at delaying ejaculation in numerous clinical studies, however their side effects can be worse that the problem they are fixing

Herbal PE Pills

In an analysis of herbal premature ejaculation pills on the market, two things stand out: (1) they each have a different combination of ingredients and (2) they all make claims of far-reaching capabilities while often providing warnings that alternative products are useless compared to theirs.  These PE pills are often labeled as being a solution for sexual stamina, a term that means different things to different people. Be most careful of chinese herbal medication. 

Few Common Ingredients

Herbal medicines have been around for thousands of years. You would think that if an herb or combination of herbs effectively allowed men to have longer-lasting sex, this would be one of the most popular herbs on earth. The fact that there is very little overlap in key ingredients of commonly advertised sexual enhancement pills (see table) leads one to believe that it's more probable that none of these pills work. If such an herb existed, wouldn't it be included in every product? Let's take a look at two ingredients that are common to more than one product.


One ingredient that appears in three of the products is L-arginine, an amino acid found it meat, fish and poultry. In the body, L-arginine is converted to nitric oxide, a molecule that is used to control blood flow. PDE-5 inhibitors indirectly elevate nitric oxide in order to increase blood flow to the penis to treat erectile dysfunction (ED). Some studies have shown improvement in ED for men taking L-arginine but no such positive results for premature ejaculation have been found.
L-arginine is also quite a common ingredient in many penile enhancement pills. Recently, hundreds of these performance enhancement pill manufacturers have been banned by the FDA  for illegally tainting their so-called "natural" supplements with sildenafil or other PDE-5 inhibitors in order to deliver better results. This practice is so common that one must conclude that L-arginine does not have the efficacy as an erectile dysfunction treatment. It also shows the misleading practice of male sexual enhancement supplement manufacturers claiming improvement in every aspect of male sexual performance: ED, PE, libido and even penis size.

St. John's Wort

An herb found in two of the products is St. John's Wort.  It's used in many herbal supplements  for a variety ailments including: depression, somatic symptom disorders, alcoholism, wounds, burns, muscle pain, ADHD, Parkinson's disease, premenstrual syndrome and irritable bowel syndrome.  Given that St. John's Wort has been used as a medicine since the time of ancient Greece, its effectiveness for PE would surely have been discovered long ago. A similar statement could be made about the other herbs on the list.

Questionable Advertising

Another concern about these premature ejaculation pills are their claims for positive results and warnings against like competitive products. None of these herbal supplements have been evaluated by the FDA nor do they follow any particular guidelines for safety and efficacy. 


Most of these herbal premature ejaculation pill products make bold statements about performance and not just for PE.  Here's a sampling taken from product websites: 

DetainX - "The Only Scientific and Proven Way To Stop Premature Ejaculation."
Ejacutrol - "Simply take Ejacutrol before sex and last three, five, or even ten times longer." "Ejacutrol is the most advanced and effective product on the market."
PrematureX - "... men who use PrematureX report better erections, increased libido, more stamina and a greater level of semen production."
DelayMaxx - "Last 4 - 5 Times Longer On Bed & Have Harder & Longer Lasting Erection On Demand!"
RizerXL - "Generate rock-hard erections. Stop premature ejaculation. Increase stamina and endurance. Increase ejaculate amount. Treat erectile dysfunction. Increase your libido."
Duramale  - "Increases fertility, stronger and firmer erections, increases sexual libido and stamina." 


What's interesting, and somewhat amusing, is that some of these PE pill makers bash one other's products as hype, low-quality, rip-offs and useless.

DetainX -  "... there have been dozens of ripoff artists and bogus copycats that claim to have a product that achieves the same results  ..."
Duramale  - "While there are low-quality products on the market that claim to help get rid of PE and promote themselves as miracle-working "last longer pills, ..."
DelayMaxx - "I know what it's like to be ripped off time and time again by useless pills."  "Many dishonest companies try to take advantage of men and scam them out of their money."

Delay Pills and Stamina Pills

There are two pharmaceutical technologies that have clinical data indicating its effectiveness for premature ejaculation. Tramadol, which is indicated to treat pain, is prescribed off-label to treat PE.  In spite of some clinical success, Tramadol is falling out of favor as new topical treatments with low side effect profiles are emerging. 

Traditional anti-depressants in the form of SSRIs (e.g. Paxil, Zoloft) have had positive clinical results but are not approved for use in the U.S. specifically as a treatment for PE but are also prescribed off-label. In addition to numerous side effects, including loss of libido, these SSRIs must be taken daily to be effective. A fast-acting SSRI, Priligy and its generic, Dapoxetine, have shown in clinical studies to be effective when taken 30 minutes to three hours prior to sex.  However, drawbacks to Priligy / Dapoxetine are the same side effects as traditional SSRIs, although generally to a lesser extent.  The drug is not approved by the FDA for use in the U.S.

Where to Buy the Best Over the Counter Premature Ejaculation Pills

Walmart, Walgreens, and GNC are the stores with the largest variety of over the counter (OTC) premature ejaculation pills.

You should not take any type of delay pills with consulting a doctor.

See your doctor prior to considering any of these treatments.

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