Fluoxetine For Premature Ejaculation: How Effective Is It?

It's estimated 30% of all men experience premature ejaculation. Learn about why Fluoxetine may be an effective treatment for PE.

Dr. Jed Kaminetsky
Expert in male sexual health, leading Urologist in USA
by Dr. Jed Kaminetsky Last updated 11/22/2022
Dr. Jed Kaminetsky

Dr. Jed Kaminetsky

Dr. Jed Kaminetsky M.D. is an American Board Certified Urologist and earned his Medical Degree at New York University. In his tenure he became a member of the American Urological Association and the American College of Surgeons. Dr. Kaminetsky pioneered the minimally invasive Rezum BPH treatment and is an expert in male and female dysfunction.


Absorption Pharmaceuticals LLC (Promescent) has strict informational citing guidelines and relies on peer-reviewed studies, academic or research institutions, medical associations, and medical experts. We attempt to use primary sources and refrain from using tertiary references and only citing trustworthy sources. Each article is reviewed, written, and updated by Medical Professionals or authoritative Experts in a specific, related field of practice. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • "Premature ejaculation: definition and prevalence | International Journal of Impotence Research." Nature.com, 2022, https://www.nature.com/articles/3901507. Accessed on Oct, 24, 2022.
  • "Fluoxetine (Prozac) | NHS." Nhs.uk, 2022, https://www.nhs.uk/medicines/fluoxetine-prozac/. Accessed on Oct, 24, 2022.
  • "What is Serotonin? | Simply Psychology." Simplypsychology.org, 2022, https://www.simplypsychology.org/what-is-serotonin.html. Accessed on Oct, 24, 2022.
  • "The Efficacy of Fluoxetine in the Treatment of Premature Ejaculation: A Double-Blind Placebo Controlled Study | AUA Journals." auajournals.org, 1996, https://www.auajournals.org/doi/abs/10.1016/S0022-5347%2801%2965467-3. Accessed on Oct, 24, 2022.
  • Arafa M, Shamloul R. A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire. Ther Clin Risk Manag. 2007 Aug;3(4):527-31. PMID: 18472973; PMCID: PMC2374931. Accessed on Oct, 24, 2022.
  • Jenkins LC, Gonzalez J, Tal R, Guhring P, Parker M, Mulhall JP. Compliance With Fluoxetine Use in Men With Primary Premature Ejaculation. J Sex Med. 2019 Dec;16(12):1895-1899. doi: 10.1016/j.jsxm.2019.09.017. Epub 2019 Nov 15. PMID: 31735615; PMCID: PMC7526797. Accessed on Oct, 24, 2022.
  • Volpi-Abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013 Winter;13(4):533-40. PMID: 24358002; PMCID: PMC3865832. Accessed on Oct, 24, 2022.
  • Chen GH, Song SQ, Zhang YQ. [A clinical study on psycho-behavior therapy for premature ejaculation]. Zhonghua Nan Ke Xue. 2009 Oct;15(10):929-31. Chinese. PMID: 20112744. Accessed on Oct, 24, 2022.
  • Zhang W, Zhang Y, Gao J, Peng D, Zhang Y, Wu X, Liu G, Dai Y, Jiang H, Zhang X. Poor Sleep Quality is an Independent Risk Factor for Acquired Premature Ejaculation. Nat Sci Sleep. 2022 Feb 22;14:255-263. doi: 10.2147/NSS.S349511. PMID: 35228824; PMCID: PMC8881919. Accessed on Oct, 24, 2022.
The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

مشاركة المقال: