Heard about liquid Cialis? Learn what it is, how it works, and why doctors, not shady websites, should handle it.
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Liquid Cialis is simply a liquid formulation of tadalafil (the active drug in Cialis), not a different medication.
In the U.S., Cialis (tadalafil) is only FDA-approved as a tablet for erectile dysfunction.
The only FDA-approved liquid form of tadalafil (TADLIQ®) is for pulmonary arterial hypertension (PAH) – not for treating ED.
In practice, “liquid Cialis” refers to a compounded solution of tadalafil made to order by a licensed pharmacy for patients who need a liquid dose (for example, those who can’t swallow pills).
This guide explains what that really means, how (and if) liquid tadalafil is used, and the key safety and legal points to consider.
To fully grasp how tadalafil works, it’s important to put this information into context.
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor: it relaxes blood vessels in the penis to improve blood flow and help produce an erection.
Tadalafil has FDA approval to treat erectile dysfunction, benign prostatic hyperplasia (BPH), and PAH).
Liquid tadalafil contains the same active drug, so it works the same way and has the same potential benefits and side effects as tablet Cialis.
Because “liquid Cialis” is just tadalafil in liquid form, the only way to get it is through a custom prescription.
Liquid Cialis is not available in the U.S. because the manufacturer, Eli Lilly and Company, does not produce a liquid formulation.
But Cialis and its generic form (Tadalafil) are currently available only in tablet form in the United States.
It’s not an over-the-counter product, and it’s not bought like a supplement.
A doctor (or telehealth provider) must prescribe the liquid formulation, and only a licensed compounding pharmacy can legally mix the medication into a dropper bottle.
The pharmacy might label the bottle with a concentration (e.g., milligrams per milliliter) and give you a dropper or syringe to measure doses.
If you find any “liquid Cialis” for sale online without a prescription, it’s almost certainly an illegal, unregulated product (often labeled “research chemical”) – avoid these entirely.
You might wonder why anyone would need tadalafil in liquid form.
The main reasons are logistical: difficulty swallowing pills or a need for flexible dosing. For example, people with certain swallowing problems (dysphagia) or those allergic to tablet binders/fillers may prefer a liquid dose.
Some patients (such as children with pulmonary arterial hypertension or those on feeding tubes) may need a solution for medical reasons.
However, it’s important to note that Cilais (liquid vs tablet) isn’t inherently “faster” or stronger for ED.
But the advantage only comes with a doctor’s supervision, since this use is off-label and not FDA-approved for ED.
A liquid dose is chosen for practical reasons, not because it makes the drug work better.
Studies indicate liquid tadalafil starts working in about 30 minutes, just like the pill, and its effects last the same 24 to 36 hours.
Most men still take it about 30 to 60 minutes before sexual activity, since it generally needs a half-hour to kick in.
When used properly, liquid tadalafil could be just as effective as tablets.
Any “benefit” of a liquid form is usually convenience (for those who truly need it).
Liquid tadalafil is dosed the same way in milligrams as the tablet; the only difference is that you measure the amount using a liquid volume.
For example, ED dosing guidelines still apply: an as-needed dose is often 10 mg taken a couple of hours before sex (adjusted between 5 to 20 mg per response), and daily therapy is typically 2.5 to 5 mg once daily.
The compounding pharmacy’s label will tell you how many milligrams of tadalafil are in each milliliter of solution (e.g., 20 mg/mL), and you measure that with the dropper.
It’s critical to use the dropper (or syringe) that comes with the medication – don’t guess the volume. For instance, if the solution is 10 mg per mL, then 0.5 mL (one-half of the dropper) would be a 5 mg dose.
Always double-check the math with your doctor or pharmacist.
Never eyeball the dose: even a small error in liquid measurements can lead to under-dosing (no effect) or overdosing (dangerous effects)
When taking liquid tadalafil, treat it just like any other precise medication: measure carefully with the dropper.
Read the label for “mg/mL” and take exactly the amount prescribed.
To use, dispense the drops under your tongue or into your mouth and swallow (unless your doctor specifies a different method).
Because it works like a tablet, most men plan to take it 30 to 60 minutes before sexual activity.
Whether liquid or pill, tadalafil’s duration of effect is the same (roughly 24 to 36 hours), so timing and frequency of doses remain unchanged.
The main benefit of liquid tadalafil is convenience for certain patients (e.g. easier to swallow, adjustable dosing).
Otherwise, it doesn’t work any better than the pill.
In fact, experts emphasize that liquid and tablet forms should have the same dosing and efficacy.
No official study shows a faster onset for ED; any claims of “super-quick” effect come from anecdotal or preliminary reports, not FDA data.
Likewise, the risk of side effects or interactions is essentially the same as with tablets.
Tadliq oral suspension is FDA-approved for PAH, not ED. Future studies might reveal off-label uses.
Off-label Tadliq prescriptions for ED are currently unknown.
Avoid using Tadliq for unintended purposes like ED. Compounded liquid tadalafil isn’t FDA-approved for ED, and there’s no standardized dosing guide or clinical studies for ED.
It must be used under close medical guidance. Costs can be higher (insurance might not cover compounding).
And patients must be extra careful about storage and handling (liquid medicines can degrade over time or if not stored properly).
If you ever consider it, discuss fully with your doctor whether a liquid makes sense for you.
Liquid tadalafil carries the same side effects as regular Cialis, since the active drug is identical.
Common side effects (usually mild) include:
Headache
Flushing (reddening of face/neck)
Stuffy or runny nose
Indigestion or nausea
Back or muscle pain
These often go away after a few doses.
Serious side effects are rare but critical. They might include:
Chest pain (or pressure)
Priapism (a prolonged, painful erection)
evere dizziness,
sudden vision or hearing loss
Painful erection lasting more than four hours (priapism).
In particular, an overdose of tadalafil (taking too much liquid by accident) can cause extremely low blood pressure, fainting, and permanent vision or hearing damage.
If any of these occur, seek medical help immediately.
As with any PDE5 inhibitor, you must use liquid tadalafil exactly as prescribed.
Do not mix it with nitrates (drugs for chest pain, e.g. nitroglycerin) under any circumstances, because the combination can cause a dangerous drop in blood pressure.
Also, avoid taking multiple ED medications at once.
Tell your doctor about all other drugs or supplements you take – especially alpha-blockers, blood pressure meds, antifungals, or HIV protease inhibitors – as these can interact with tadalafil.
Because liquid doses can be potent, measure carefully and don’t “double up” if you think you missed a dose.
Remember that tadalafil is a prescription drug. There is no legitimate over-the-counter (OTC) version of Cialis.
You need a doctor’s prescription and must buy through a licensed pharmacy.
Never trust sites that claim you can buy “liquid Cialis” or similar without a prescription. Those are almost certainly illegal products with uncertain ingredients.
Only use a reputable compounding pharmacy that requires your prescription and follows FDA guidance – even then, be aware that compounding errors can happen, so follow your provider’s instructions and check labels carefully.
In the U.S., liquid Cialis is not FDA-approved for ED.
Cialis (tadalafil) is FDA-approved only as a tablet for treating ED or BPH.
If a physician prescribes a liquid formulation, it is an unapproved, off-label use and must be made by a compounding pharmacy with a valid prescription.
The only FDA-approved liquid tadalafil product (TADLIQ®) is labeled for pulmonary hypertension.
Because of this, federal law requires a prescription to legally obtain liquid tadalafil.
State boards regulate compounding pharmacies, and pharmacies must follow strict procedures.
If you come across any “liquid Cialis” products sold without a prescription or via foreign websites, be extremely cautious – such products violate FDA regulations and may be counterfeit or contaminated.
Always get tadalafil (in any form) from a legitimate U.S. pharmacy with your doctor’s prescription.
If you can’t take Cialis tablets, there are a few other prescription options and strategies:
Other PDE5 drugs
Tadalafil is not the only ED drug.
A doctor might prescribe sildenafil (generic Viagra), vardenafil (Levitra/Staxyn), or avanafil (Stendra) instead.
These come only as tablets, but some have different onset and side effect profiles that might work better for you.
Different formulations
Cialis itself comes in daily low-dose tablets (5 mg) as well as higher as-needed doses, which might be easier to swallow for some.
Some compounding pharmacies also offer orally disintegrating tablets or sublingual drops of tadalafil for specific cases.
Non-pill treatments
Devices like vacuum erection pumps, injected medications, or urethral suppositories are other FDA-approved ways to treat ED without oral pills.
Lifestyle and counseling
Addressing underlying causes (diabetes, high blood pressure, obesity, stress, and smoking) can improve ED over time. Sometimes therapy for performance anxiety also helps.
Always discuss alternatives with your healthcare provider. They can tailor treatment to your needs safely.
Is there a legal “liquid Cialis” I can buy?
No. In the U.S., no FDA-approved liquid version of Cialis exists for ED.
The only way to get liquid tadalafil legally is via a doctor’s prescription for compounding.
Be extremely wary of any product marketed as “liquid Cialis” online without a prescription – those are not legitimate medications.
How do I take the right dose in liquid form?
The compounding pharmacy will label the solution (for example, “5 mg tadalafil per 0.5 mL”).
It typically comes with a dropper or syringe.
Use that device to measure exactly the amount your doctor prescribed – for instance, to take 10 mg, you might draw 2 mL if the solution is 5 mg/mL.
Follow the label’s instructions carefully. Do not guess or eyeball the dose.
What are “research chemicals” labeled as tadalafil?
Research chemical tadalafil” is a marketing term used by sellers to bypass prescription laws.
These substances are not legally sold for human use in the U.S., and buying or using them can be risky.
They may contain inconsistent or incorrect doses, impurities, or no tadalafil at all.
Only use FDA-approved or pharmacy-compounded tadalafil with a valid prescription.
Where can I buy liquid Cialis (tadalafil) in the U.S.?
You can’t buy “liquid Cialis” over the counter or online legally.
In the U.S., it’s only available through licensed compounding pharmacies with a doctor’s prescription.
These pharmacies can legally prepare a liquid tadalafil solution for patients who need it.
Avoid any website claiming to sell liquid Cialis without a prescription these are not FDA-approved and could be dangerous or counterfeit.
The safest way is to consult your healthcare provider and ask if a compounded liquid formulation is appropriate for you.
How do you take liquid tadalafil or liquid Cialis?
Use the dropper or syringe provided by your compounding pharmacy to measure the exact dose prescribed by your doctor (for example, 5 mg or 10 mg).
The medication can be swallowed directly, usually about 30 to 60 minutes before sexual activity, unless you’re on a daily low-dose regimen.
Always measure carefully; liquid tadalafil can be potent, and even small dosing errors can affect safety or effectiveness.
Are the side effects different with liquid Cialis?
No, the side effects are the same as the tablet form.
Expect possible headaches, flushing, a stuffy nose, and muscle aches. Serious effects (priapism, chest pain, vision changes) require immediate medical attention.
Because liquid forms can be more prone to dosing errors, be extra careful not to take too much.
Taking too high a dose of tadalafil (liquid or pill) can dangerously lower your blood pressure or cause vision/hearing loss.
How do I get liquid tadalafil if I can’t swallow pills?
Talk to your doctor. If a liquid form is medically needed (for example, difficulty swallowing), the doctor can write a prescription specifying a compounded liquid.
A licensed compounding pharmacy would then prepare the solution to your specs.
You should get it from a pharmacy that dispenses by prescription. Do not attempt to order a DIY mixture or an unapproved product.
Will liquid Cialis act faster than the tablet?
In practice, no substantial difference is expected.
Tadalafil in any form generally starts to work in about 30–60 minutes.
Health information sources note that both liquid and tablet tadalafil have essentially the same onset and duration.
Official data do not back any claim of a “super-quick” liquid version.
In short: “Liquid Cialis” is not a different drug – it’s tadalafil in liquid form, prepared by a compounding pharmacy under prescription.
It’s used almost exclusively when tablets won’t do (for example, swallowing difficulties).
The drug works the same way, with similar dosing guidelines and side effects.
Because it’s not FDA-approved for ED, it must be handled carefully: get a prescription, use a reputable compounding pharmacy, and measure your doses exactly.
If you see any “liquid Cialis” products sold without a prescription, avoid them entirely.
Always consult your healthcare provider for guidance on ED treatment – they can discuss whether a liquid formulation is appropriate for you or suggest other effective options.
Our online healthcare provider can help you find a safe and effective erectile dysfunction treatment tailored to your needs, including tadalafil and other ED medications.
Our team has over a decade of experience in the sexual wellness field and are experts in sexual dysfunctions, like premature ejaculation. We help couples and individuals better understand treatment options available for different types of sexual needs and educate the public on all things related to intimacy. All of our authored content is medically reviewed for accuracy and reliability.
Absorption Pharmaceuticals LLC (Promescent) has strict informational citing guidelines and relies on peer-reviewed studies, academic or research institutions, medical associations, and medical experts. We attempt to use primary sources and refrain from using tertiary references and only citing trustworthy sources. Each article is reviewed, written, and updated by Medical Professionals or authoritative Experts in a specific, related field of practice. You can find out more about how we ensure our content is accurate and current by reading our editorial policy.
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National Institute of Diabetes and Digestive and Kidney Diseases. (2024, October). Treatment for erectile dysfunction. U.S. Department of Health and Human Services. https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/treatment. Accessed on Oct 29, 2025.
National Institute of Diabetes and Digestive and Kidney Diseases. (2024, October). Symptoms & causes of erectile dysfunction. U.S. Department of Health and Human Services. https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/symptoms-causes. Accessed on Oct 29, 2025.
Drugs.com. (2024, November 13). Why does Cialis take at least 12–14 hours to work? Drugs.com Medical Answers. https://www.drugs.com/medical-answers/12-14-hours-yo-best-results-taking-20mg-cialis-3416019. Accessed on Oct 29, 2025.
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Chiang, J., Yafi, F. A., Dorsey, P. J., & Hellstrom, W. J. G. (2017). The dangers of sexual enhancement supplements and counterfeit drugs to “treat” erectile dysfunction. Translational Andrology and Urology, 6(1), 12–19. https://pmc.ncbi.nlm.nih.gov/articles/PMC5313300/. Accessed on Oct 29, 2025.
Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2017). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: A systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731–1740. https://pmc.ncbi.nlm.nih.gov/articles/PMC5603624/. Accessed on Oct 29, 2025.
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