Premature ejaculation pills, with so many options, how do you know which ones work and which ones to avoid? We've got the answers.
Whether they're called premature ejaculation pills, delay pills, or last longer in bed pills, they can potentially help with prolonging sexual performance.
Roughly one in three men experience premature ejaculation, meaning they ejaculate uncontrollably in a minute or less of sexual intercourse.
The most popular medications for premature ejaculation are Dapoxetine (Priligy), Lexapro, Zoloft.
While these drugs may help most men, you should be conscious of the side effects that many premature ejaculations pills bring. Symptoms such as diarrhea, dizziness, dry mouth, headache, insomnia, nausea, and loss of libido can occur.
A safe and effective alternative is Promescent® Delay Spray, but you can also try a more holistic approach such as doing Kegels, using the squeeze technique, or trying the edging method.
Most men, and their partners, who deal with premature ejaculation, understandably, aren’t content with this.
With that said, here is everything you need to know about premature ejaculation pills.
The best premature ejaculation pills that may help with lasting longer in bed come in two main categories:
Over-the-counter premature ejaculation pills can be found online or behind a glass case at sex shops and convenience stores.
However, there is little evidence to show that they can successfully treat premature ejaculation.
If you're looking for premature ejaculation pills that actually work, then it’s worth looking into prescription medications.
Some doctors agree that certain drugs have the potential to stop premature ejaculation.
However, this is what's known as off-label use since they were originally developed to treat depression.
Doctors have a lot of leeways when it comes to prescriptions and can pretty much prescribe any legal medication for any reason.
So there's no reason a doctor can't, for example, take a medicine used to treat depression and repurpose it to treat premature ejaculation if it also has that effect.
Let’s now take a closer look at some specific premature ejaculation pills, from herbs to medications.
Have you ever heard of delayed ejaculation supplements? You’ll often hear about them advertised as a way of increasing male sexual stamina and treating premature ejaculation.
But when looking at the herbs currently on the market, a couple of key things stand out.
Firstly: Different brands often have very different combinations of ingredients.
Secondly: Many brands make outrageous claims about their effectiveness, and they sometimes warn against competing products, making for a mess of contradictory claims.
That said, there is one common ingredient in many of these products, and there is some science to suggest that it just might work.
St. John’s wort is an herb used in many supplements, and it’s thought to help with a variety of ailments, such as:
At least two studies have concluded that it’s a potentially promising treatment, including a 2010 study of 50 men with PE, which suggested that this herb may assist in helping with premature ejaculation by increasing the neurotransmitter serotonin in the brain.
In addition, a 2005 study suggested that St. John’s wort seems to affect the ability of the vas deferens (the sperm carrying tube) to contract, which is another mechanism through which this herb may potentially prevent premature ejaculation.
Moving on from herbs, let’s take a look at the prescription medicines sometimes used to treat premature ejaculation.
Dapoxetine belongs to a class of antidepressants called selective serotonin reuptake inhibitors (SSRI).
It slows down the brain's ability to reabsorb serotonin, which regulates mood.
Allowing serotonin to remain active in the brain for longer periods of time can create a greater sense of psychological well-being.
Dapoxetine is fast-acting, but it also leaves the body quickly, meaning that serotonin reuptake inhibition doesn't last too long.
A noted side effect of Dapoxetine and other SSRIs is that they help with premature ejaculation.
Clinical trials have found that Dapoxetine can delay premature ejaculation by several minutes.
This, combined with the fast-acting, fast-dissipating nature of the drug, makes it a reasonable choice for occasional use as a last longer in bed pill.
In 2005, the FDA rejected Dapoxetine as a treatment for premature ejaculation.
Since that time, the drug has remained in Phase III clinical trials.
Dapoxetine is patent-protected, with no generic versions commercially available; as a result, it tends to be expensive.
A 2017 study noted that the discontinuation rate of Dapoxetine among men taking it for PE was quite high. Many men discontinued the drug due to the cost, side effects, and dissatisfaction with the results.
Lexapro (trade name for escitalopram) is another SSRI, one of many approved by the FDA in the United States as a treatment for depression.
However, some doctors prescribe it off-label to stop premature ejaculation.
Unlike Dapoxetine, Lexapro takes about ten days to notice the effects and as much as two to three weeks for it to take effect fully.
Thus, users need to stay on a continued daily regimen to maintain the sexual effects rather than taking this drug intermittently as needed.
A study found that Lexapro was effective in helping men to increase their ejaculation time.
Sertraline, better known by the trade name Zoloft, is another SSRI, and it is available in generic form.
Sertraline was approved by the FDA in 1991 and remains one of the most commonly-prescribed psychiatric medications.
Again, it is sometimes prescribed off-label for premature ejaculation, and at least one Australian study showed promise. In this study, 46 men between the ages of 22 and 63—all of whom had a mean IELT of 1 minute—were given escalating doses of sertraline over a period of several weeks.
These men took longer to ejaculate as the dosage increased, suggesting that Sertraline is a potentially viable treatment for premature ejaculation.
However, the researchers also found that, as the dosage increased, more and more men reported an inability to reach orgasm at all, which suggests that finding the optimal dosage is essential.
Besides SSRIs, the following medications have also been explored as current or future pills to treat premature ejaculation:
Tramadol is a strong, narcotic-like analgesic often administered to treat pain, but it’s occasionally prescribed off-label to treat premature ejaculation.
Studies have shown that it does indeed help with PE.
However, it isn’t entirely clear how it works to delay ejaculation.
That said, it does tend to inhibit the reuptake of the neurotransmitters norepinephrine and serotonin, which suggests that the mechanism of action might be similar to SSRIs.
If you are considering this route, you should be aware that there are additional, much more serious side effects that you can read about here.
You know these as erectile dysfunction drugs: sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
These medications promote blood flow to the penis and help men maintain erections. Some evidence suggests that they could also help some men delay ejaculation.
For example, a 2007 study concluded that sildenafil is a “very effective and safe” treatment for PE and can increase IELT. However, not all studies have produced consistent results.
For instance, a 2005 study found that sildenafil did not significantly increase IELT. However, it did increase sexual satisfaction for men with PE, in part because it reduced the length of time it took for men to get another erection following ejaculation.
This medication is ordinarily used to treat narcolepsy, a sleep disorder.
Experiments are currently underway testing its effectiveness as a premature ejaculation pill, and preliminary evidence has been promising.
For example, a 2016 study found that Modafinil was linked to a “modest” improvement in IELT among men with PE.
This treatment for benign prostate tumors may hold promise as a premature ejaculation pill. A 2017 study found that men taking this drug reported longer IELTs.
While there is evidence supporting a lot of different premature ejaculation pills, it’s important to recognize that none of these medications are magic cures and that you have to keep taking them to maintain the effects.
Also, while these drugs may help some men, they don’t work for everyone.
Quite simply, a pill that instantly makes any guy last all night in earth-shattering splendor, just doesn't exist.
Once your doctor has written you a prescription, you can fill it at any pharmacy, just like any other prescription.
For OTC treatments, you can find them online and in various sex shops and other stores.
Ultimately that is a decision for you to make, in consultation with your doctor, even if you decide to go the OTC route.
No pill completely cures premature ejaculation, and there’s often a trade-off between:
You could potentially find yourself on a long, frustrating merry-go-round, trying pill after pill.
That's time and mental energy you could spend on exercises and other treatments that can delay ejaculation more readily.
Delay sprays, like Promescent, offer an on-demand medical solution to fast ejaculation and come at the recommendation of over 2,000 Urologists.
The spray contains the topical anesthetic lidocaine, which lightly desensitizes your penis, allowing you to feel less sensation during intercourse, thereby delaying ejaculation.
The great part is that you can still experience all the same great sensations of sex, just slightly muted, so you can still enjoy a satisfying orgasm.
Simply apply the spray ten minutes before intercourse, and you’re good to go!
Kegel exercises strengthen the muscles at the base of the penis. Often used to control urinary incontinence, they can also increase your ability, over time, to delay your ejaculation.
To perform them:
This exercise can be practiced while masturbating or during sex with a partner. The goal is to help you identify the "point of no return," after which ejaculation is inevitable.
As you feel orgasm approaching, stop the stimulation and give your penis a chance to relax. Then begin stimulation again.
You may take it too far sometimes and ejaculate early. That’s okay; over time, you will begin to recognize the physical sensations of your "point of no return" and adjust stimulation during sex to delay it.
As you feel the point of no return approach, stop stimulation and firmly squeeze the head of the penis to suppress the ejaculatory response.
With time, it will build muscle memory and help you control ejaculation.
It's natural to want a quick fix to a frustrating problem.
Talk to your doctor about whether premature ejaculation pills are right for you.
Be sure to discuss any underlying health issues as well as what you can expect when it comes to results and side effects.
Be wary of over-the-counter premature ejaculation pills, and if you decide to try one, do ample research beforehand and consult with your healthcare professional.
It’s important to not only know what you’re putting in your body but where it came from.
In the meantime, consider alternative treatments like delay spray from Promescent; it offers a fantastic on-demand treatment option for PE that has helped over 500,000 men just like you enjoy better, longer-lasting sex.
Dr. Justin Lehmiller is a social psychologist and Research Fellow at The Kinsey Institute. He is author of the blog Sex and Psychology and the popular book Tell Me What You Want: The Science of Sexual Desire and How It Can Help You Improve Your Sex Life. He is also a prolific researcher who has published more than 50 academic works, including a textbook titled The Psychology of Human Sexuality that is used in college classrooms around the world. Dr. Lehmiller is one of the media's go-to experts on sex and has been interviewed by The Wall Street Journal, The New York Times, and CNN; he has also appeared on dozens of radio, podcast, and television programs.
Absorption Pharmaceuticals LLC (Promescent) has strict informational citing guidelines and relies on peer-reviewed studies, academic or research institutions, medical associations, and medical experts. We attempt to use primary sources and refrain from using tertiary references and only citing trustworthy sources. Each article is reviewed, written, and updated by Medical Professionals or authoritative Experts in a specific, related field of practice. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
National Center for Biotechnology Information Staff. 2019 September 12. Premature ejaculation: Does medication work?. NCBI. https://www.ncbi.nlm.nih.gov/books/NBK547554/. Accessed 28 Jan 2022.
UroToday Int J. 2010 June. Safety and Efficacy of the Herbal Drug Hypericum Perforatum for the Treatment of Premature Ejaculation OurToday. https://www.urotoday.com/volume-3-2010/vol-3-issue-3/36187-safety-and-efficacy-of-the-herbal-drug-hypericum-perforatum-for-the-treatment-of-premature-ejaculation-2229105.html. Accessed 28 Jan 2022.
Raffaele Capasso, Francesca Borrelli, Vittorino Montanaro, Vincenzo Altieri, Francesco Capasso, Angelo A Izzo. 2005 June. Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility. PubMed. https://pubmed.ncbi.nlm.nih.gov/15879886/. Accessed 28 Jan 2022.
Chris G McMahon 2010 July. Dapoxetine for premature ejaculation. PubMed. https://pubmed.ncbi.nlm.nih.gov/20540653/. Accessed 28 Jan 2022.
Hyun Jun Park, MD, PhD, Nam Cheol Park, MD, PhD, Tae Nam Kim, MD, Seung Ryong Baek, MD, Kyung Min Lee, MS, and Sangmin Choe, MD, PhD. 2017 April 05. Discontinuation of Dapoxetine Treatment in Patients With Premature Ejaculation: A 2-Year Prospective Observational Study. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440632/. Accessed 28 Jan 2022.
PharmaTimes Staff. 2005 October 27. FDA turns down dapoxetine for premature ejaculation. PharmaTimes. https://www.pharmatimes.com/news/fda_turns_down_dapoxetine_for_premature_ejaculation_998783. Accessed 28 Jan 2022.
Arafa M, Shamloul R. A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire. Ther Clin Risk Manag. 2007;3(4):527-531. Accessed on Aug, 15, 2023.
C G McMahon. 1998 September. Treatment of premature ejaculation with sertraline hydrochloride. PubMed. https://pubmed.ncbi.nlm.nih.gov/9788108/. Accessed 28 Jan 2022.
Bayoumy I Eassa and Mohamed A El-Shazly. 2012 October 29. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739134/. Accessed 28 Jan 2022.
Wei-Fu Wang, Yang Wang, Suks Minhas, David J Ralph. 2007 April 26. Can sildenafil treat primary premature ejaculation? A prospective clinical study. International Journal of Urology. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1442-2042.2007.01606.x. Accessed 28 Jan 2022.
Chris G. McMahon MB, BS, FACSHP,Bronwyn G. A. Stuckey BA, MBBS, FRACP,Morten Andersen MD,Kenneth Purvis MD, PhD,Nandan Koppiker MD, FRCP,Scott Haughie MSc,Mitra Boolell MD. 2001 April 11. Efficacy of Sildenafil Citrate (Viagra) in Men with Premature Ejaculation. Wiley Online Library. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1743-6109.2005.20351.x. Accessed 28 Jan 2022.
Murat Tuken, Murat Can Kiremit, Ege Can Serefoglu. 2016 August. On-demand Modafinil Improves Ejaculation Time and Patient-reported Outcomes in Men With Lifelong Premature Ejaculation. ScienceDirect. https://www.sciencedirect.com/science/article/abs/pii/S0090429516301406. Accessed 28 Jan 2022.
Yoshikazu Sato, Toshikazu Otani, Toshiyasu Amano, Tohru Araki, Nobuyuki Kondou, Masanori Matsukawa, Musashi Tobe, Kazunori Haga, Kousuke Uchida, Ichiya Honma. 2017 June 18. Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. https://onlinelibrary.wiley.com/doi/full/10.1111/iju.13392. Accessed 28 Jan 2022.
Chris G. McMahon. 2007 April-June. Premature ejaculation. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721550/. Accessed 28 Jan 2022.